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Invitrogen
MSL2 Monoclonal Antibody (3A4)
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产品信息
MA5-22114
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
3A4
抗原
MSL2 (NP_060603, 478 a.a. ~ 575 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.2-1.0 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Peptide Sequence: GQRCPCYSNR KACLDCICRG CQNSYMANGE KKLEAFAVPE KALEQTRLTL GINVTSIAVR NASTSTSVIN VTGSPVTTFL AASTHDDKSL DEAIDMRF
靶标信息
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin-protein ligase MSL2; Male-specific lethal 2-like 1; Male-specific lethal-2 homolog; Male-specific lethal-2 homolog 1; MSL-2; MSL2-like 1; RING finger protein 184
基因别名: KIAA1585; MSL-2; MSL2; MSL2L1; RNF184
UniProt ID: (Human) Q9HCI7
Entrez Gene ID: (Human) 55167
