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Invitrogen
MTBP Polyclonal Antibody
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产品信息
PA5-110909
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: DAKELLKYFT SDGLPIGDLQ PLPIQKGEKT FVLTPELSPG KLQVLPFEKA SVCHYHGIEY CLDDRKALER DGGFSELQSR LIRYETQTTC TR
Highest antigen sequence indentity to the following orthologs: Rat - 91%, Mouse - 93%.
靶标信息
MTBP inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. The protein may play a role in MDM2-dependent TP53/p53 homeostasis in unstressed cells. The protein inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of TP53/p53 and its subsequent degradation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hdm2; HDMX; hMTBP; MDM2 (mouse double minute 2)-binding protein, 104kD; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa; Mdm2-binding protein; MGC5370; MGC71221
基因别名: MDM2BP; MTBP
UniProt ID: (Human) Q96DY7
Entrez Gene ID: (Human) 27085
