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Invitrogen
MTRR Polyclonal Antibody
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MTRR Antibody (PA5-89941) in WB
Western blot analysis of MTRR in extracts of various cell lines. Samples were incubated with MTRR Polyclonal antibody (Product # PA5-89941) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 20s.
产品信息
PA5-89941
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 50-230 of human MTRR (NP_0024452)
偶联物
形式
Liquid
浓度
0.71 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: TAPLVVVVST TGTGDPPDTA RKFVKEIQNQ TLPVDFFAHL RYGLLGLGDS EYTYFCNGGK IIDKRLQELG ARHFYDTGHA DDCVGLELVV EPWIAGLWPA LRKHFRSSRG QEEISGALPV ASPASSRTDL VKSELLHIES QVELLRFDDS GRKDSEVLKQ NAVNSNQSNV VIEDFESSLT R; Positive Samples: A-549, HeLa, LO2, 293T; Cellular Location: Cytoplasm, Cytoplasm
靶标信息
Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing); AqCbl reductase; Aquacobalamin reductase; Methionine synthase reductase; methionine synthase reductase, mitochondrial; MGC129643; MSR
基因别名: cblE; MSR; MTRR
UniProt ID: (Human) Q9UBK8
Entrez Gene ID: (Human) 4552
NADPH-hemoprotein reductase activity
protein binding
FMN binding
oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
[methionine synthase] reductase activity
aquacobalamin reductase (NADPH) activity
flavin adenine dinucleotide binding
NADP binding
NADPH binding
FAD binding
oxidoreductase
sulfur amino acid metabolic process
DNA methylation
methionine metabolic process
methionine biosynthetic process
cobalamin metabolic process
methylation
S-adenosylmethionine cycle
homocysteine catabolic process
folic acid metabolic process
oxidation-reduction process
negative regulation of cystathionine beta-synthase activity
