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NeoBiotechnologies
MUC4 (Mucin 4/Gastric Mucin) Monoclonal Antibody (MUC4/2863)
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产品信息
4585-MSM3-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
MUC4/2863
抗原
Recombinant fragment (around aa 1730-1864) of human MUC4 protein (exact sequence is proprietary).
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product cellular localization: Apical cell membrane, Cell membrane, Cytoplasm, Nucleus, Secreted.
Positive control: Kidney: Distal tubuli and collecting ducts must show a strong cytoplasmic MUC1 staining while the staining should be at least moderate in the parietal and visceral sheets of the Bowman's capsule and largely absent in proximal tubuli.
Tissue specificity: Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform Y is expressed in tumor cells only.
靶标信息
Nearly all mucosal surfaces are protected by mucin transmembrane glycoproteins, from bronchioles to corneas to reproductive tracts. Mucin 4 (MUC4) is membrane-bound and is important in protecting and lubricating. MUC4 expression is erroneous in many carcinomas and sarcomas, including fibromyoxoid sarcoma and pancreatic adenocarcinoma. Immunohistochemical staining for MUC4 has been discussed as a potential biomarker for detection of these cancers. MUC4 seems to be most predominantly affected in Asian diseases - Taiwanese infertility and endometriosis, as well as gallstone formation in Chinese men, are connected to MUC4, where similar diseases in other populations do not share these MUC4 mutations. Because MUC4 is so important in mucosal surface protection, it is not surprising that it has been implicated as failing in many metastatic cancer invasions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ascites sialoglycoprotein; ASGP; ASGP1; MUC-4; mucin 4, tracheobronchial; Mucin-4; Mucin4; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin
基因别名: ASGP; HSA276359; MUC-4; MUC4
UniProt ID: (Human) Q99102
Entrez Gene ID: (Human) 4585
