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Invitrogen
MUSK Recombinant Rabbit Monoclonal Antibody (PSH05-68)
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MUSK Antibody (MA5-52463) in ICC/IF
Immunofluorescence analysis of MUSK was performed using 70% confluent log phase L6 and RSC96 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with MUSK Recombinant Rabbit Monoclonal Antibody (PSH05-68) (Product # MA5-52463) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alex... View More
产品信息
MA5-52463
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH05-68
抗原
Recombinant protein within human musk aa 1-516/869.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 40% glycerol, 0.1% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: Mouse skeletal muscle tissue lysate, rat skeletal muscle tissue lysate, human skeletal muscle tissue, mouse skeletal muscle tissue, rat skeletal muscle tissue.
Sequence Similarities: 100% Mouse/Rat.
Subcellular Location: Postsynaptic cell membrane.
Predicted band size: 97 kDa.
靶标信息
MUSK plays an important and selective role in many aspects of skeletal muscle development and function through the initial step of postsynaptic differentiation and formation of end-plate bands in cooperation with Rapsyn. Communication between cells is often mediated by receptors on the surface of the target cell that are triggered by specific ligands released by other cells. Receptor tyrosine kinase activity is strictly regulated by the binding of the appropriate ligand to the extracellular active site of the receptor. MuSK has been shown to be part of the agrin signaling complex and plays an important role in the development and architectural maintenance of the neuromuscular junction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC126323; MGC126324; muscle localized kinase 2; muscle specific kinase (neural fold/somite kinase 1); Muscle, skeletal receptor tyrosine protein kinase; Muscle, skeletal receptor tyrosine-protein kinase; muscle, skeletal, receptor tyrosine kinase; muscle-specific kinase receptor; muscle-specific protein kinase secretory isoform; muscle-specific tyrosine kinase receptor MuSK; Muscle-specific tyrosine protein kinase receptor; Muscle-specific tyrosine-protein kinase receptor; MuSK; RP23-170A3.1
基因别名: CMS9; FADS; Mdk4; Mlk; MUSK; Nsk1; Nsk2; Nsk3
UniProt ID: (Human) O15146, (Mouse) Q61006, (Rat) Q62838
Entrez Gene ID: (Human) 4593, (Mouse) 18198, (Rat) 81725
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
metal ion binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
PDZ domain binding
transmembrane signal receptor
positive regulation of protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
neuromuscular junction development
memory
regulation of synaptic growth at neuromuscular junction
positive regulation of gene expression
peptidyl-tyrosine phosphorylation
cell differentiation
protein autophosphorylation
skeletal muscle acetylcholine-gated channel clustering
positive regulation of protein geranylgeranylation
regulation of transcription, DNA-templated
protein phosphorylation
signal transduction
negative regulation of gene expression
phosphorylation
positive regulation of synaptic transmission, cholinergic
receptor clustering
positive regulation of neuron apoptotic process
positive regulation of synaptic growth at neuromuscular junction
positive regulation of peptidyl-tyrosine phosphorylation
response to electrical stimulus
long-term synaptic potentiation
response to muscle activity
response to axon injury
retina development in camera-type eye
cochlea development
