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Invitrogen
MYO5A Polyclonal Antibody
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MYO5A Antibody (PA5-101689) in ICC/IF
Immunocytochemistry analysis of MYO5A in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with MYO5A polyclonal antibody (Product # PA5-101689) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-101689
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MYO5A(Accession Q9Y4I1), corresponding to amino acid residues L1783-P1833.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total MYO5A.
靶标信息
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: actin-associated molecular motor; alternatively spliced; molecular motor; dilute lethal-20J protein; dilute myosin heavy chain, non-muscle; dilute-opisthotonus; flailer; motor protein; myosin 5a; myosin V; myosin VA (heavy chain 12, myoxin); myosin, heavy polypeptide kinase; myosin-12; myosin-Va; myoxin; OTTMUSP00000017756; OTTMUSP00000019176; OTTMUSP00000046608; unnamed protein product
基因别名: 9630007J19Rik; d; d-120J; Dbv; Dop; flail; flr; GS1; MVa; MYH12; MYO5; MyoVA; MYR12; Sev-1
UniProt ID: (Human) Q9Y4I1, (Mouse) Q99104, (Rat) Q9QYF3
Entrez Gene ID: (Human) 4644, (Mouse) 17918, (Rat) 25017
microfilament motor activity
RNA binding
motor activity
catalytic activity
protein binding
ATP binding
ATPase activity
small GTPase binding
actin filament binding
SNARE binding
actin binding
calcium ion binding
calmodulin binding
enzyme binding
protein kinase binding
identical protein binding
ATP-dependent protein binding
macromolecular complex binding
calcium-dependent protein binding
disordered domain specific binding
melanin metabolic process
exocytosis
post-Golgi vesicle-mediated transport
endocytosis
actin filament organization
chemical synaptic transmission
visual perception
protein transport
vesicle-mediated transport
macroautophagy
regulation of exocytosis
phenol-containing compound metabolic process
actin filament-based movement
vesicle transport along actin filament
insulin secretion
melanocyte differentiation
locomotion involved in locomotory behavior
secretory granule localization
melanosome localization
melanosome transport
cellular response to insulin stimulus
negative regulation of dopamine secretion
dopamine metabolic process
melanin biosynthetic process
odontogenesis
myelination
long-chain fatty acid biosynthetic process
pigmentation
developmental pigmentation
hair follicle maturation
synapse organization
endoplasmic reticulum localization
establishment of vesicle localization
negative regulation of synaptic transmission, glutamatergic
protein-containing complex assembly
protein localization to plasma membrane
establishment of endoplasmic reticulum localization to postsynapse
regulation of postsynaptic cytosolic calcium ion concentration
axo-dendritic protein transport
reactive gliosis
positive regulation of cellular response to insulin stimulus
positive regulation of protein localization to plasma membrane
positive regulation of vascular associated smooth muscle cell migration
positive regulation of cytochrome-c oxidase activity
regulation of Golgi organization
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