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Invitrogen
Matuzumab Recombinant Human Monoclonal Antibody (Matuzumab)
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Matuzumab Antibody (MA5-47997) in ELISA
ELISA analysis of Matuzumab recombinant monoclonal antibody (Product # MA5-47997) was performed by coating plate with Matuzumab-Fc at a concentration of 5 µg/mL. A 3-fold serial dilution from 100 to 0.1 ng/mL of the antibody was performed. For detection, a 1:4,000 dilution of HRP labelled anti-human kappa light chain antibody was used.
产品信息
MA5-47997
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
Matuzumab
抗原
Domain III of the extracellular domain of human EGRF.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Specificity: This antibody binds the extracellular domain III of the human EGFR and does not cross react with murine EGFR. It was also reported that residues S460/G461 in EGFR domain III are essential components of the epitope. This antibody binds at a site distinct from the EGF binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding. This antibody can only recognize the active form of EGFR. The antibody binds to both glyco- and aglyco receptor forms.
靶标信息
Matuzumab is a humanized monoclonal antibody used in cancer treatment. It has a high affinity for EGFR, frequently associated with the growth of blood vessels in malignancy, facilitating tumor growth and survival.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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