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Fabgennix
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Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MeCp-2 protein; MECP2; MECP2A; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_1; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_2; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_3; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_5; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_6; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_7; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_8; Methyl-CpG-binding protein 2; Rett Syndrome transcript 1; Rett syndrome; MECP2B; transcript variant; transcriptional repressor; involved in Rett syndrome disease; unnamed protein product
基因别名: 1500041B07Rik; AUTSX3; D630021H01Rik; Mbd5; MECP2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; WBP10
UniProt ID: (Human) P51608, (Mouse) Q9Z2D6, (Rat) Q00566
Entrez Gene ID: (Human) 4204, (Mouse) 17257, (Rat) 29386