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Invitrogen
Mebendazole Recombinant Mouse Monoclonal Antibody (1D1)
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Mebendazole Antibody (MA566427) in SDS-PAGE
SDS-PAGE characterization of Mebendazole under reducing conditions. Lane M: Protein marker (kDa); Lane MBZ: Purified Mebendazole Recombinant Monoclonal (Product # MA566427). Mebendazole showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-461.
产品信息
MA566427
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1D1
抗原
Conjugate of MBZ hapten and KLH.
偶联物
形式
Liquid
浓度
11.5 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Mebendazole, originally developed as an anti-parasitic drug, has been repurposed for potential use in oncology due to its demonstrated anti-cancer properties. Structurally, mebendazole is a benzimidazole derivative, which allows it to interfere with microtubule formation, a mechanism crucial for its anti-parasitic and anti-cancer effects. The gene location and specific genetic interactions of mebendazole are not directly applicable as it functions primarily through biochemical pathways rather than genetic modulation. Functionally, mebendazole has shown efficacy in preclinical models of various cancers, including breast cancer, glioblastoma, medulloblastoma, colon cancer, pancreatic cancer, and thyroid cancer, with low toxicity in humans. Its ability to prevent metastasis and its safety profile make it a promising candidate for drug repositioning in cancer therapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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