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Invitrogen
Menin Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115569
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MEN1(Accession O00255), corresponding to amino acid residues S183-M233.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total MEN1.
靶标信息
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Menin; multiple endocrine neoplasia 1
基因别名: AW045611; MEN1; menin; SCG2
UniProt ID: (Mouse) O88559, (Rat) Q9WVR8
Entrez Gene ID: (Mouse) 17283, (Rat) 29417
four-way junction DNA binding
Y-form DNA binding
DNA binding
chromatin binding
double-stranded DNA binding
protein binding
histone-lysine N-methyltransferase activity
protein binding, bridging
sequence-specific DNA binding
transcription regulatory region DNA binding
protein N-terminus binding
R-SMAD binding
molecular_function
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
ossification
leukocyte homeostasis
negative regulation of protein phosphorylation
osteoblast fate commitment
osteoblast development
type B pancreatic cell differentiation
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
cell cycle arrest
negative regulation of cell proliferation
response to UV
embryo development
response to gamma radiation
negative regulation of cell-substrate adhesion
chromatin modification
histone methylation
hemopoiesis
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of histone methylation
positive regulation of protein binding
regulation of activin receptor signaling pathway
histone lysine methylation
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of cell differentiation
negative regulation of osteoblast differentiation
positive regulation of osteoblast differentiation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JNK cascade
negative regulation of organ growth
embryonic skeletal system morphogenesis
negative regulation of epithelial cell proliferation
positive regulation of cell division
negative regulation of telomerase activity
palate development
maternal process involved in female pregnancy
regulation of type B pancreatic cell proliferation
response to transforming growth factor beta
negative regulation of cell cycle G1/S phase transition
mitotic cell cycle
brain development
decidualization
cellular response to glucose stimulus
cellular response to peptide hormone stimulus
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