Invitrogen

Menin Recombinant Rabbit Monoclonal Antibody (K01_1K75)

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问题与答案

问题与答案

问题与答案

抗体检测数据 (1)

Menin Antibody in Western Blot (WB)

Menin Antibody in Western Blot (WB)

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Menin Antibody (MA563150) in WB

Western blot analysis of Menin in various lysates. Samples were incubated with Menin recombinant monoclonal (Product # MA563150). Samples: K562, C6 lysates.

Menin Antibody in Western Blot (WB)

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Menin Antibody in Western Blot (WB) — Western blot analysis of Menin in various lysates. Samples were incubated with Menin recombinant monoclonal (Product # MA563150). Samples: K562, C6 lysates.

产品信息

MA563150

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

产品规格

种属反应

Human, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

K01_1K75

抗原

A synthetic peptide of human Menin.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

50mM tris glycine, pH 7.4, with 40% glycerol, 150mM NaCl, 0.05% BSA

内含物

0.01% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Menin; multiple endocrine neoplasia 1; multiple endocrine neoplasia I

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基因别名: MEAI; MEN1; menin; SCG2

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UniProt ID: (Human) O00255, (Rat) Q9WVR8

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Entrez Gene ID: (Human) 4221, (Rat) 29417

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four-way junction DNA binding Y-form DNA binding chromatin binding double-stranded DNA binding protein binding histone-lysine N-methyltransferase activity protein binding, bridging transcription regulatory region DNA binding protein N-terminus binding R-SMAD binding molecular_function DNA binding sequence-specific DNA binding

negative regulation of transcription from RNA polymerase II promoter MAPK cascade mitotic cell cycle ossification leukocyte homeostasis negative regulation of protein phosphorylation osteoblast fate commitment osteoblast development type B pancreatic cell differentiation chromatin remodeling transcription, DNA-templated cellular response to DNA damage stimulus cell cycle arrest brain development negative regulation of cell proliferation response to UV response to gamma radiation negative regulation of cell-substrate adhesion histone methylation hemopoiesis positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of histone methylation positive regulation of protein binding regulation of activin receptor signaling pathway histone lysine methylation positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of cell differentiation negative regulation of osteoblast differentiation positive regulation of osteoblast differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of organ growth decidualization embryonic skeletal system morphogenesis negative regulation of epithelial cell proliferation positive regulation of cell division negative regulation of telomerase activity palate development maternal process involved in female pregnancy regulation of type B pancreatic cell proliferation cellular response to glucose stimulus cellular response to peptide hormone stimulus response to transforming growth factor beta negative regulation of cell cycle G1/S phase transition DNA repair beta-catenin-TCF complex assembly