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Invitrogen
Modafinil Recombinant Mouse Monoclonal Antibody (1E2)
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Modafinil Antibody (MA566411) in SDS-PAGE
SDS-PAGE characterization of Modafinil under reducing conditions. Lane M: Protein marker (kDa); Lane MDF: Purified Modafinil Recombinant Monoclonal (Product # MA566411). Modafinil showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-343.
产品信息
MA566411
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1E2
抗原
Conjugate of MDF hapten and KLH.
偶联物
形式
Liquid
浓度
5.7 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Modafinil is a wake-promoting agent primarily targeting the dopamine transporter (DAT), leading to reuptake inhibition and increased dopamine levels in the synaptic cleft. Structurally, modafinil is characterized by a sulfoxide functional group, which has been modified in various analogues to enhance biological activity. These analogues have shown potential in cognitive enhancement and treatment of psychostimulant use disorders. Modafinil derivatives have been synthesized through substitution and coupling reactions, demonstrating anti-inflammatory effects by inhibiting nitrite production and expression of iNOS and COX-2 in cultured BV2 cells. The gene information related to modafinil biosimilars focuses on its atypical dopamine uptake inhibition, which is crucial for its therapeutic effects in sleep disturbances and psychostimulant use disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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