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Invitrogen
MuERVL-Gag Polyclonal Antibody
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MuERVL-Gag Antibody (PA5-119739) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of MuERVL-Gag in mouse 3-cell stage embryo (red). The cells were incubated overnight at 4°C with MuERVL-Gag Polyclonal Antibody (Product # PA5-119739) at a 1:100 dilution (shown in red) and phalloidin (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).
产品信息
PA5-119739
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within C-terminal residues of Gag
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: Mouse embryo.
靶标信息
A large number of retrotransposons are expressed when the zygotic genome is first transcribed, including the endogenous retroviruses (ERVs), LINE-1 elements, and the non-autonomous SINE elements. At the 2C stage, MuERV-L/MERVL retrovirus-like elements are transiently de-repressed and produce 3% of the transcribed mRNAs. Following the 2C stage, MERVL-retroelement expression is silenced. The newly study discovered that this regulated pattern of MERVL expression overlapped with greater than one hundred 2C-specific genes that have co-opted regulatory elements from these foreign retroviruses to initiate their transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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