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Invitrogen
Mupadolimab Humanized Recombinant Human Monoclonal Antibody
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产品信息
MA5-59501
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Mupadolimab is a humanized monoclonal antibody that targets CD73, an enzyme expressed on various immune cells, including B cells and T cells. CD73 plays crucial roles in processes such as immunomodulation and adenosine production. CD73 (also known as ecto-5'-nucleotidase) is encoded by the NT5E gene located on chromosome 6q14-q21. It is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that catalyzes the dephosphorylation of extracellular AMP to adenosine and inorganic phosphate. Functionally, CD73 plays critical roles in various physiological and pathological processes. It modulates immune response by generating adenosine, which has immunosuppressive effects, thus aiding tumor cells in evading the immune system. CD73 is implicated in cancer cell proliferation, migration, invasion, and tumor angiogenesis, making it a significant target for cancer immunotherapy. Its expression is also associated with memory T-cell function, suggesting its pivotal role in adaptive immunity. Moreover, mutations in NT5E are linked to a rare genetic disorder known as arterial calcifications due to deficiency of CD73.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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