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Invitrogen
Mycobacterium tuberculosis MPT63 Polyclonal Antibody
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Mycobacterium tuberculosis MPT63 Antibody (PA5-117613) in WB
Western Blot analysis of MPT63 using Mycobacterium tuberculosis MPT63 Polyclonal Antibody (Product # PA5-117613) at 2 µg/mL. Lane 1: Recombinant Mycobacterium tuberculosis Immunogenic protein MPT63 protein 1 µg. Lane 2: Recombinant Mycobacterium tuberculosis Immunogenic protein MPT63 protein 0.1 µg. Secondary: Goat polyclonal to rabbit IgG at 1:10,000 dilution. Predicted band size: 17 kDa. Observed band siz... View More
产品信息
PA5-117613
产品规格
种属反应
Bacteria
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Mycobacterium tuberculosis Immunogenic protein MPT63 protein (30-159aa)
偶联物
形式
Liquid
浓度
4 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody has been tested in direct-ELISA
靶标信息
MPT63 is a small, major secreted protein of unknown function from Mycobacterium tuberculosis that has been shown to have immunogenic properties and has been implicated in virulence. A BLAST search identified that MPT63 has homologs only in other mycobacteria, and is therefore mycobacteria specific. As MPT63 is a secreted protein, mycobacteria specific, and implicated in virulence, MPT63 is an attractive drug target against the deadliest infectious disease, tuberculosis (TB). As part of the TB Structural Genomics Consortium, the X-ray crystal structure of MPT63 was determined to 1.5-Angstrom resolution with the hope of yielding functional information about MPT63. The structure of MPT63 is an antiparallel beta-sandwich immunoglobulin-like fold, with the unusual feature of the first beta-strand of the protein forming a parallel addition to the small antiparallel beta-sheet. MPT63 has weak structural similarity to many proteins with immunoglobulin folds, in particular, Homo sapiens beta2-adaptin, bovine arrestin, and Yersinia pseudotuberculosis invasin. Although the structure of MPT63 gives no conclusive evidence to its function, structural similarity suggests that MPT63 could be involved in cell-host interactions to facilitate endocytosis/phagocytosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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