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Invitrogen
Mycophenolic acid Recombinant Mouse Monoclonal Antibody (5E8)
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Mycophenolic acid Antibody (MA566406) in SDS-PAGE
SDS-PAGE characterization of Mycophenolic acid under reducing conditions. Lane M: Protein marker (kDa); Lane MPA: Purified Mycophenolic acid Recombinant Monoclonal (Product # MA566406). Mycophenolic acid showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-346.
产品信息
MA566406
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5E8
抗原
Conjugate of MPA hapten and KLH.
偶联物
形式
Liquid
浓度
4.1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Mycophenolic acid (MPA) is a potent immunosuppressive agent primarily used in organ transplantation and treatment of autoimmune diseases. It is a natural product derived from the fungus Penicillium brevicompactum and was the first antibiotic to be isolated and crystallized. MPA functions by inhibiting inosine monophosphate dehydrogenase, a key enzyme in the de novo synthesis of purine nucleotides, thereby suppressing lymphocyte proliferation. The biosynthesis of MPA involves compartmentalized pathways within the fungal cells, highlighting its complex structural features, including a 6-alkyl-2,4-dihydroxybenzoate moiety. Recent studies have explored novel derivatives of MPA, aiming to enhance its cytotoxic and antimicrobial activities, which have shown promising results against various cell lines. The development of biosimilars for MPA is supported by the FDA's bioequivalence standards, offering cost-effective alternatives for immunosuppressive therapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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