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Mab 414 reacts with myosin-containing elements in most cell types. Antigen localization: cytoplasm In Western blot experiments the antibody reacts with a 75kD part of the heavy chain (epitope location on a myosin-common sitechain), no reaction with light chains. It is not reactive with alpha-cardiac myosin. Positive control: muscle, myofibrils (chicken)
Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: epididymis luminal protein 71; fast 2a myosin heavy chain; inclusion body myopathy 3, autosomal dominant; MGC133384; MyHC-2a; MyHC-2b; MyHC-2x; MyHC-IIa; MyHC-IIb; MyHC-IIx/d; Myosin heavy chain 1; Myosin heavy chain 2; Myosin heavy chain 2a; Myosin heavy chain 2b; Myosin heavy chain 2x; Myosin heavy chain 4; Myosin heavy chain IIa; Myosin heavy chain IIb; Myosin heavy chain IIx/d; Myosin heavy chain, skeletal muscle; myosin heavy chain, skeletal muscle, adult; Myosin heavy chain, skeletal muscle, adult 1; Myosin heavy chain, skeletal muscle, adult 2; Myosin heavy chain, skeletal muscle, fetal; Myosin heavy chain, skeletal muscle, juvenile; myosin, heavy chain 1, skeletal muscle, adult; myosin, heavy chain 2, skeletal muscle, adult; myosin, heavy chain 4, skeletal muscle; myosin, heavy polypeptide 1, skeletal muscle, adult; myosin, heavy polypeptide 2, skeletal muscle, adult; myosin, heavy polypeptide 4, skeletal muscle; Myosin-1; Myosin-2; Myosin-4; skeletal muscle myosin heavy chain II-a; type IIA myosin heavy chain; unnamed protein product
基因别名: A530084A17Rik; AI506973; HEL71; IBM3; IId; IId/x; MdMs; MHC; MHC-2X/D; MHC2A; MHC2B; MHC2X/D; Minimsc; Minmus; MM; MYH-2B; MYH1; MYH2; MYH2A; MYH2B; MYH4; MYHa; MYHas8; MyHC-2A; MyHC-2B; MyHC-2x; MyHC-2X/D; MyHC-IIa; MyHC-IIb; MyHC-IId/x; MYHC-IIX; MyHC-IIx/d; Myhs-f; Myhs-f1; Myhs-f2; MYHSA1; MYHSA2; Myhsf; Myhsf1; Myhsf2; MYPOP
UniProt ID: (Human) P12882, (Human) Q9UKX2, (Human) Q9Y623, (Rabbit) Q28641, (Mouse) Q5SX40, (Mouse) Q5SX39
Entrez Gene ID: (Human) 4619, (Chicken) 427788, (Human) 4620, (Human) 4622, (Rabbit) 100009548, (Rabbit) 100125991, (Mouse) 17879, (Mouse) 17882, (Mouse) 17884