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Invitrogen
Myostatin Recombinant Rabbit Monoclonal Antibody (46H48L45)
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Myostatin Antibody (705023) in WB
Western blot was performed using Myostatin Recombinant Rabbit Monoclonal Antibody (46H48L45) (Product # 705023) and ~45 kDa band corresponding to Myostatin was observed in RD cells treated with PTI compared to other cell lines, similarly in tissues, bands were observed in mouse skeletal muscle, rat skeletal muscle compared to mouse liver and rat liver. Whole cell extracts treated with PTI (1X for 4 hrs) (30 µg lysate) of RD (Lane 1), HeLa (Lane 2), PANC-1 (Lane 3), SH-SY5Y (Lane 4) as seen in Fig. a.; tissue extracts (30 µg lysate) of mous... View More
产品信息
705023
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
46H48L45
抗原
Protein corresponding to human Myostatin [aa24-aa266]
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Recombinant Rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
The protein encoded by this gene is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GDF-8; Growth/differentiation factor 8; H-Myo-Propeptide; H-Myostatin; Myostatin; myostatin-b; transforming growth factor-beta superfamily member; unnamed protein product
基因别名: GDF8; MSLHP; MSTN
UniProt ID: (Human) O14793
Entrez Gene ID: (Human) 2660
transforming growth factor beta receptor signaling pathway
muscle organ development
skeletal muscle tissue development
response to gravity
positive regulation of lamellipodium assembly
positive regulation of macrophage chemotaxis
skeletal muscle atrophy
negative regulation of muscle hypertrophy
skeletal muscle satellite cell differentiation
myoblast migration involved in skeletal muscle regeneration
response to muscle activity
ovulation cycle process
response to testosterone
skeletal muscle tissue regeneration
response to estrogen
response to ethanol
negative regulation of myoblast differentiation
positive regulation of transcription, DNA-templated
negative regulation of insulin receptor signaling pathway
muscle cell cellular homeostasis
negative regulation of skeletal muscle tissue growth
response to glucocorticoid
response to electrical stimulus
negative regulation of protein kinase B signaling
trophoblast cell migration
cellular response to hypoxia
cellular response to dexamethasone stimulus
negative regulation of skeletal muscle satellite cell proliferation
negative regulation of satellite cell differentiation
negative regulation of myoblast proliferation
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