Invitrogen

N-cadherin Polyclonal Antibody

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2个已发表图片
2 篇参考文献
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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

PA5-17526

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
查看1篇已发表文章 1篇已发表文章

免疫组化 (IHC)

-
查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:100
-

免疫沉淀 (IP)

1:25
-
产品规格

种属反应

Bovine, Fruit fly, Human, Mouse, Non-human primate, Rat, Zebrafish

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Two synthetic peptides corresponding to two conserved regions of human N-Cadherin

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

9 µg/mL

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10985390

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, neuronal; cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; Cadherin-N; Cadherin2; calcium-dependent adhesion protein, neuronal; CD325; CDw325; CDw325 antigen; cell adhesion molecule; glass onion; labyrinth; N-cadherin; N-cadherin 1; Neural cadherin; Parachute; ZNCAD

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基因别名: bib; CD325; CDH2; CDHN; CDw325; glo; lyr; N-cadherin; NCAD; pac; wu:fb47h04

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UniProt ID: (Human) P19022, (Mouse) P15116, (Rat) Q9Z1Y3, (Zebrafish) Q90275

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Entrez Gene ID: (Human) 1000, (Bovine) 281062, (Mouse) 12558, (Rat) 83501, (Zebrafish) 30291

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功能
calcium ion binding protein binding beta-catenin binding protein kinase binding protein phosphatase binding protein complex binding alpha-catenin binding gamma-catenin binding nitric-oxide synthase binding enzyme binding metal ion binding cadherin binding cadherin
参与通路
cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules glial cell differentiation calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell migration cerebral cortex development regulation of myelination adherens junction organization regulation of Rho protein signal transduction positive regulation of MAPK cascade cell-cell adhesion mediated by cadherin blood vessel morphogenesis brain morphogenesis homeostasis of number of cells regulation of axonogenesis striated muscle cell differentiation positive regulation of muscle cell differentiation protein heterooligomerization radial glial cell differentiation neuroepithelial cell differentiation regulation of oligodendrocyte progenitor proliferation establishment of protein localization to plasma membrane negative regulation of canonical Wnt signaling pathway neuroligin clustering involved in postsynaptic membrane assembly neuronal stem cell population maintenance regulation of postsynaptic density protein 95 clustering positive regulation of synaptic vesicle clustering regulation of signal transduction cell-cell adhesion synapse assembly single organismal cell-cell adhesion regulation of protein localization cell morphogenesis cartilage condensation neural crest cell migration somitogenesis neuron migration neuron cell-cell adhesion multicellular organism development ectoderm development nervous system development axon guidance axonal fasciculation brain development peripheral nervous system development motor neuron axon guidance cardioblast differentiation spinal cord patterning cell migration in hindbrain hindbrain structural organization ventricular system development neural tube development cell differentiation midbrain development hindbrain development embryonic pectoral fin morphogenesis dorsal fin morphogenesis post-anal tail morphogenesis tissue regeneration odontogenesis regulation of eye photoreceptor cell development establishment of epithelial cell apical/basal polarity embryonic eye morphogenesis axial mesoderm structural organization mesoderm morphogenesis generation of neurons semicircular canal morphogenesis regulation of synaptic transmission, glutamatergic dorsal convergence retina development in camera-type eye embryonic retina morphogenesis in camera-type eye auditory receptor cell stereocilium organization cilium morphogenesis pigment cell development sensory epithelium regeneration commissural neuron axon guidance cell migration involved in somitogenic axis elongation motor neuron migration cell-cell adhesion via plasma-membrane adhesion molecules negative regulation of neural precursor cell proliferation
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