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Abnova
NAAA Monoclonal Antibody (5E3)
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产品信息
H00027163-M01
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
5E3
抗原
NAAA (NP_055250, 36 a.a. approximately 104 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: FNVSLDSVPE LRWLPVLRHY DLDLVRAAMA QVIGDRVPKW VHVLIGKVVL ELERFLPQPF TGEIRGMCD
靶标信息
N-acylsphingosine amidohydrolase-like 1 (ASAHL), commonly referred to as acid ceramidase-like protein, is a gene located on human chromosome 22q13.31. ASAHL encodes a protein that functions as a ceramidase, responsible for hydrolyzing ceramide into sphingosine and fatty acid, which are pivotal for cell signaling pathways that regulate cell growth, differentiation, and apoptosis. Though similar to acid ceramidase, ASAHL's specific biological role and tissue distribution remain active research areas, suggesting potential involvement in lipid metabolism and cellular homeostasis. Dysregulation of ceramidase activity, including ASAHL, is linked to various diseases, such as cancer, neurodegenerative disorders, and metabolic syndromes, due to the crucial role of sphingolipid signaling in these conditions. The gene's activity may influence ceramide levels within cells, impacting susceptibility to apoptosis and other cell fate decisions, highlighting its importance in pathophysiological contexts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Acid ceramidase-like protein; Acylsphingosine deacylase NAAA; ASAH-like protein; N-acylethanolamine-hydrolyzing acid amidase; N-acylsphingosine amidohydrolase-like
基因别名: 2210023K21Rik; 3830414F09Rik; ASAHL; NAAA; PLT
UniProt ID: (Human) Q02083, (Mouse) Q9D7V9
Entrez Gene ID: (Human) 27163, (Mouse) 67111
transcription factor binding
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
histone deacetylase activity
protein-N-terminal asparagine amidohydrolase activity
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
hydrolase activity
iprodione amidohydrolase activity
(3,5-dichlorophenylurea)acetate amidohydrolase activity
4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
didemethylisoproturon amidohydrolase activity
N-isopropylacetanilide amidohydrolase activity
N-cyclohexylformamide amidohydrolase activity
isonicotinic acid hydrazide hydrolase activity
cis-aconitamide amidase activity
gamma-N-formylaminovinylacetate hydrolase activity
N2-acetyl-L-lysine deacetylase activity
O-succinylbenzoate synthase activity
indoleacetamide hydrolase activity
N-acetylcitrulline deacetylase activity
N-acetylgalactosamine-6-phosphate deacetylase activity
diacetylchitobiose deacetylase activity
chitooligosaccharide deacetylase activity
cysteine protease
