Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
NACA Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 2
NACA Antibody (40-1000) in WB
Western blot analysis was performed on whole cell extracts of SH-SY5Y (Lane 1), Caco-2 (Lane 2), A431 (Lane 3), and HEK-293 (Lane 4). The blot was probed with Anti-NACA (alpha-NAC) Rabbit Polyclonal Antibody (Product # 40-1000, 2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A 23 kDa band corresponding to NACA (alpha-NAC) was observed across the cell lines tested. Known quantity of protein samples were electrop... View More
产品信息
40-1000
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Raised against the C-term of human NAC Alpha.
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
NACA prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). It binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. NACA also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites), and may act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Alpha-NAC; Alpha-NAC, muscle-specific form; Alpha-NAC/1.9.2; NAC-alpha; nascent polypeptide-associated complex alpha subunit; Nascent polypeptide-associated complex subunit alpha; Nascent polypeptide-associated complex subunit alpha, muscle-specific form; nascent-polypeptide-associated complex alpha polypeptide; skNAC
基因别名: AL022831; AL024382; Gm1878; HSD48; mKIAA0363; NAC-alpha; NACA; NACA1; skNAC
UniProt ID: (Human) Q13765, (Mouse) P70670
Entrez Gene ID: (Human) 4666, (Rat) 288770, (Mouse) 17938
transcription, DNA-templated
regulation of transcription, DNA-templated
cardiac ventricle development
negative regulation of striated muscle cell apoptotic process
skeletal muscle tissue regeneration
positive regulation of skeletal muscle tissue growth
regulation of skeletal muscle fiber development
myoblast migration
heart trabecula morphogenesis
negative regulation of transcription from RNA polymerase II promoter involved in heart development
positive regulation of transcription from RNA polymerase II promoter involved in heart development
regulation of nucleic acid-templated transcription
positive regulation of cell proliferation involved in heart morphogenesis
transport
protein transport
