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Invitrogen
NACC2 Polyclonal Antibody
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产品信息
PA5-61624
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: RVRKRWLPKI KSMLPEGVEM YRTVMGSAAA SVPLDPEFPP AAAQVFEQRI YAERRGDAAT IVALRTDAVN VDLSAAAN
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
靶标信息
Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
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生物信息学
蛋白别名: BEN domain containing 9; BTB (POZ) domain containing 14A; BTB/POZ domain-containing protein 14A; MGC23427; NAC-2; NACC family member 2, BEN and BTB (POZ) domain containing; Nucleus accumbens-associated protein 2; Repressor with BTB domain and BEN domain; transcription repressor with a BTB domain and a BEN domain
基因别名: BEND9; BTBD14; BTBD14A; BTBD31; NAC-2; NAC2; NACC2; RBB
UniProt ID: (Human) Q96BF6
Entrez Gene ID: (Human) 138151
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
histone deacetylase activity
protein binding
protein homodimerization activity
histone deacetylase binding
transcription, DNA-templated
positive regulation of cell proliferation
negative regulation of cell proliferation
posttranscriptional regulation of gene expression
histone deacetylation
cellular protein complex localization
negative regulation of transcription, DNA-templated
protein homooligomerization
negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
