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Bethyl Laboratories
NACC2/BTBD14A Polyclonal Antibody
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NACC2/BTBD14A Antibody (A304-991A) in WB
Detection of human and mouse NACC2 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-NACC2 antibody (Product # A304-991A) (lot A304-991A-1) used for WB at 0.4 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
产品信息
A304-991A
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 175 to 225 of human Nucleus accumbens-associated protein 2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BEN domain containing 9; BTB (POZ) domain containing 14A; BTB/POZ domain-containing protein 14A; MGC23427; NAC-2; NACC family member 2, BEN and BTB (POZ) domain containing; Nucleus accumbens-associated protein 2; Repressor with BTB domain and BEN domain; transcription repressor with a BTB domain and a BEN domain
基因别名: 0610020I02Rik; AI448087; BEND9; BTBD14; BTBD14A; BTBD31; C030048H19Rik; NAC-2; NAC2; NACC2; RBB
UniProt ID: (Human) Q96BF6, (Mouse) Q9DCM7
Entrez Gene ID: (Human) 138151, (Mouse) 67991
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
histone deacetylase activity
protein binding
protein homodimerization activity
histone deacetylase binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
posttranscriptional regulation of gene expression
histone deacetylation
cellular protein complex localization
negative regulation of transcription, DNA-templated
protein homooligomerization
negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
transcription, DNA-templated
positive regulation of cell proliferation
