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Invitrogen
NAGPA Polyclonal Antibody
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产品信息
PA5-64149
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: FFRMNSGECL GNVVSDERRV SSSGGLQNAQ FGIRRDGTLV TGYLSEEEVL DTENPFVQLL SGVVWLIRNG SIYINESQAT ECDETQETGS FSKFVNVISA RTAIGHDRKG QLVLFHADGQ TEQRGINLWE MAE
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 92%.
靶标信息
Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha-N-acetylglucosaminyl phosphodiesterase; lysosomal alpha-N-acetylglucosaminidase; Mannose 6-phosphate-uncovering enzyme; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Phosphodiester alpha-GlcNAcase
基因别名: APAA; NAGPA; UCE
UniProt ID: (Human) Q9UK23
Entrez Gene ID: (Human) 51172
