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Invitrogen
NAIF1 Polyclonal Antibody
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NAIF1 Antibody (PA5-90302) in WB
Western blot analysis of NAIF1 in extracts of various cell lines. Samples were incubated with NAIF1 Polyclonal antibody (Product # PA5-90302) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-90302
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human NAIF1 (NP_9310451)
偶联物
形式
Liquid
浓度
1.18 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MAVPAKKRKM NFSEREVEII VEELELKKHL LVNHFNAGVP LAAKSAAWHG ILRRVNAVAT CRRELPEVKK KWSDLKTEVR RKVAQVRAAV EGGEAPGPTE EDGAGGPGTG; Positive Samples: LO2, A375, 293T, OVCAR3, Mouse brain, Mouse liver, Rat brain, Rat liver; Cellular Location: Nucleus
靶标信息
Human NAIF1 is located on chromosome 9q34.11 and encodes 327 amino acids with a homeodomain-like region and two nuclear localization signals at its N-terminal region. NAIF1 is conserved across diverse species, including human, mouse, crab-eating macaque, dog, chicken and frog, and shares no obvious homology to any known genes or proteins. NAIF1 was predominantly localized in the nucleus. Overexpression of NAIF1 inhibited cell growth and induced apoptosis. Furthermore, NAIF1 transfection caused both decreases in mitochondrial membrane potential and caspase-3 activation. In summary, NAIF1 is a nuclear protein that induces apoptosis when overexpressed.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: nuclear apoptosis inducing factor 1; Nuclear apoptosis-inducing factor 1
基因别名: 2310007O20Rik; 4933440H19Rik; bA379C10.2; C9orf90; NAIF1
UniProt ID: (Human) Q69YI7, (Mouse) Q6PFD7
Entrez Gene ID: (Human) 203245, (Mouse) 71254, (Rat) 687739
