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Abnova
NALP12 Monoclonal Antibody (3B5)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00091662-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3B5
抗原
NALP12 (AAH28069, 1 a.a. approximately 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5-1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: MLRTAGRDGL CRLSTYLEEL EAVELKKFKL YLGTATELGE GKIPWGSMEK AGPLEMAQLL ITHFGPEEAW RLALSTFERI NRKDLWERGQ REDLVRDTPP GGPSSLGNQS
靶标信息
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: monarch 1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; PYPAF7; PYRIN-containing APAF1-like protein 7; regulated by nitric oxide; unnamed protein product
基因别名: CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2
UniProt ID: (Human) P59046
Entrez Gene ID: (Human) 91662
negative regulation of cytokine production
signal transduction
negative regulation of signal transduction
regulation of interleukin-18 production
negative regulation of interleukin-1 production
negative regulation of interleukin-6 production
positive regulation of interleukin-1 beta production
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MHC class I biosynthetic process
negative regulation of Toll signaling pathway
regulation of inflammatory response
negative regulation of inflammatory response
positive regulation of inflammatory response
negative regulation of NIK/NF-kappaB signaling
positive regulation of NIK/NF-kappaB signaling
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