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NALP6 Polyclonal Antibody
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NALP6 Antibody (600-401-CY4) in ICC/IF
Immunofluorescence Microscopy of NALP6 antibody. Tissue: Human brain tissue. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: NALP6 antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: NALP6 is nuclear and cytoplasmic and is a membrane protein. Staining: NALP6 as red fluorescent signal.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
600-401-CY4
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-NALP6 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide near the N-terminus of human NALP6.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappa-B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: angiotensin II/vasopressin receptor; NACHT, leucine rich repeat and PYD containing 6; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; PYPAF5; PYRIN-containing APAF1-like protein 5; unnamed protein product
基因别名: AVR; CLR11.4; NALP6; NAVR; NAVR/AVR; PAN3; PYPAF5
UniProt ID: (Human) P59044
Entrez Gene ID: (Human) 171389
acute inflammatory response
negative regulation of inflammatory response to antigenic stimulus
signal transduction
G-protein coupled receptor signaling pathway
negative regulation of I-kappaB kinase/NF-kappaB signaling
host-mediated regulation of intestinal microbiota composition
regulation of inflammatory response
positive regulation of inflammatory response
defense response to Gram-positive bacterium
protein homooligomerization
defense response to virus
pyroptosis
negative regulation of ERK1 and ERK2 cascade
antiviral innate immune response
NLRP6 inflammasome complex assembly
positive regulation of interleukin-18-mediated signaling pathway
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
