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Immunogen sequence: LPCEMACNEK LGKSVVAKVK IPEGTILTMD MLTVKVGEPK GYPPEDIFNL VGKKVLVTVE EDDTIMEELV DNHG
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 88%.
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: epididymis secretory protein Li 100; N-acetylneuraminate synthase; N-acetylneuraminate-9-phosphate synthase; N-acetylneuraminic acid 9-phosphate synthetase; N-acetylneuraminic acid phosphate synthase; N-acetylneuraminic acid synthase; RP11-404F11.3; sialic acid phosphate synthase; Sialic acid synthase
基因别名: 4632418E04Rik; BB056474; HEL-S-100; NANS; SAS; SEMDG
UniProt ID: (Human) Q9NR45, (Mouse) Q99J77
Entrez Gene ID: (Human) 54187, (Mouse) 94181, (Rat) 298071
分子生物学功能: acetyltransferase