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Invitrogen
NBS1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-86459
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 241-290 of Human Nibrin.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AT V1; AT V2; Cell cycle regulatory protein p95; FLJ10155; hNbs1; MGC87362; Nibrin; Nijmegen breakage syndrome protein 1; Nijmegen breakage syndrome protein 1 homolog; OTTHUMP00000204088; p95-NBS1
Gene Aliases: NBN; NBS; NBS1; P95
UniProt ID: (Mouse) Q9R207, (Rat) Q9JIL9
Entrez Gene ID: (Mouse) 27354, (Rat) 85482
DNA damage checkpoint
telomere maintenance
in utero embryonic development
blastocyst growth
DNA repair
double-strand break repair
cellular response to DNA damage stimulus
cell cycle
mitotic cell cycle checkpoint
mitotic G2 DNA damage checkpoint
cell proliferation
positive regulation of cell proliferation
positive regulation of protein autophosphorylation
DNA duplex unwinding
positive regulation of kinase activity
isotype switching
negative regulation of neuron differentiation
negative regulation of viral entry into host cell
regulation of fibroblast proliferation
neuromuscular process controlling balance
meiotic cell cycle
intrinsic apoptotic signaling pathway
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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