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Invitrogen
NCF2 Polyclonal Antibody
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NCF2 Antibody (PA5-88253) in IHC (P)
Immunohistochemistry analysis of NCF2 in paraffin-embedded human esophageal cancer. Samples were incubated with NCF2 Polyclonal antibody (Product # PA5-88253) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-88253
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 227-526 of human NOXA2/p67phox (NP_0004242)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
7.65 mg/mL
规格
765 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PPPRPKTPEI FRALEGEAHR VLFGFVPETK EELQVMPGNI VFVLKKGNDN WATVMFNGQK GLVPCNYLEP VELRIHPQQQ PQEESSPQSD IPAPPSSKAP GRPQLSPGQK QKEEPKEVKL SVPMPYTLKV HYKYTVVMKT QPGLPYSQVR DMVSKKLELR LEHTKLSYRP RDSNELVPLS EDSMKDAWGQ VKNYCLTLWC ENTVGDQGFP DEPKESEKAD ANNQTTEPQL KKGSQVEALF SYEATQPEDL EFQEGDIILV LSKVNEEWLE GECKGKVGIF PKVFVEDCAT TDLESTRREV; Positive Samples: THP-1, Mouse spleen; Cellular Location: Cytoplasm
靶标信息
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Defects in NCF2 are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 67 kDa neutrophil oxidase factor; chronic granulomatous disease, autosomal 2; FLJ93058; NADPH oxidase activator 2; NADPH oxidase subunit (67kDa); NADPH oxidase subunit 67 kD; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); neutrophil NADPH oxidase factor 2; unnamed protein product
基因别名: NCF-2; NOXA2; P67-PHOX; P67PHOX
UniProt ID: (Human) P19878, (Mouse) O70145
Entrez Gene ID: (Human) 4688, (Mouse) 17970
superoxide metabolic process
phagocytosis
cellular defense response
superoxide anion generation
innate immune response
respiratory burst
NADP catabolic process
response to glucose
response to lipopolysaccharide
cellular response to hormone stimulus
positive regulation of neuron apoptotic process
positive regulation of blood pressure
regulation of reactive oxygen species biosynthetic process
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
