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Invitrogen
NCF2 Recombinant Rabbit Monoclonal Antibody (7J7N3)
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NCF2 Antibody (MA5-35393) in IHC (P)
Immunohistochemistry analysis of NCF2 in paraffin-embedded mouse kidney. Samples were incubated with NCF2 Monoclonal antibody (Product # MA5-35393) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
MA5-35393
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7J7N3
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human NOXA2/p67phox (P19878)
偶联物
形式
Liquid
浓度
0.55 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: GKATVVASVV DQDSFSGFAP LQPQAAEPPP RPKTPEIFRA LEGEAHRVLF GFVPETKEEL QVMPGNIVFV LKKGNDNWAT VMFNGQKGLV PCNYLEPVEL R
靶标信息
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Defects in NCF2 are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 67 kDa neutrophil oxidase factor; FLJ93058; NADPH oxidase activator 2; NADPH oxidase subunit (67 kD); NADPH oxidase subunit (67kDa); NCF-2; ncf2; ncf2 {ECO:0000312|EMBL:FAA00361.1}; Neutrophil cytosol factor 2; Neutrophil NADPH oxidase factor 2; p67-phox
基因别名: Ncf-2; Ncf2; NOXA2; P67phox
UniProt ID: (Mouse) O70145
Entrez Gene ID: (Mouse) 17970, (Rat) 364018
NADP catabolic process
superoxide metabolic process
response to glucose
response to organic cyclic compound
response to lipopolysaccharide
cellular response to hormone stimulus
superoxide anion generation
positive regulation of neuron apoptotic process
positive regulation of blood pressure
aging
response to activity
response to progesterone
response to lipid
response to laminar fluid shear stress
response to drug
response to hyperoxia
