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Invitrogen
NCK1 Recombinant Rabbit Monoclonal Antibody (JU41-80)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-34616
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JU41-80
抗原
Recombinant protein within Human NCK1 aa 204-296.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: NIH-3T3, Hela, rat kidney tissue lysate, mouse testis tissue lysate, A431, HUVEC, LOVO, rat testis tissue, human tonsil tissue, human kidney tissue.
靶标信息
NCK1 is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytoplasmic protein NCK1; melanoma NCK protein; MGC12668; NCK adapter protein 1; NCK tyrosine kinase; non-catalytic region of tyrosine kinase; SH2/SH3 adapter protein NCK-alpha; SH2/SH3 adaptor protein NCK-alpha; unnamed protein product
基因别名: NCK; nck-1; NCKalpha
UniProt ID: (Human) P16333
Entrez Gene ID: (Human) 4690
protein kinase inhibitor activity
receptor binding
protein binding
cytoskeletal adaptor activity
protein domain specific binding
receptor signaling complex scaffold activity
protein binding, bridging
receptor tyrosine kinase binding
signaling adaptor activity
cadherin binding
ephrin receptor binding
eukaryotic initiation factor eIF2 binding
protein sequestering activity
molecular condensate scaffold activity
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
signal complex assembly
cell migration
positive regulation of actin filament polymerization
response to endoplasmic reticulum stress
regulation of translation initiation in response to endoplasmic reticulum stress
positive regulation of translation in response to endoplasmic reticulum stress
positive regulation of T cell proliferation
T cell activation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin receptor signaling pathway
ephrin receptor signaling pathway
negative regulation of T cell receptor signaling pathway
antiviral innate immune response
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of cap-dependent translational initiation
positive regulation of cap-independent translational initiation
negative regulation of PERK-mediated unfolded protein response
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
