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Invitrogen
NCK2 Polyclonal Antibody
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产品信息
PA5-29210
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human Nck beta. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: A549, HepG2.
Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (83%), Pig (90%), Chicken (92%), Bovine (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The NCK family of SH2/SH3 adaptor proteins consists of two members, NCK1 and NCK2, which couple tyrosine kinase signaling, including the EGF and PDGF receptor-pathways, to downstream signaling proteins. The NCK2 protein binds human PDGFR-b (Tyr-1009); overexpression of NCK2 inhibits PDGF-induced membrane ruffling and lamellipod formation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cytoplasmic protein NCK2; Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; noncatalytic region of tyrosine kinase, beta; SH2/SH3 adaptor protein NCK-beta
基因别名: GRB4; NCK2; NCKbeta
UniProt ID: (Human) O43639
Entrez Gene ID: (Human) 8440
immunological synapse formation
actin filament organization
signal transduction
signal complex assembly
epidermal growth factor receptor signaling pathway
regulation of epidermal growth factor-activated receptor activity
negative regulation of cell proliferation
vesicle-mediated transport
cell migration
lamellipodium assembly
positive regulation of actin filament polymerization
negative regulation of peptidyl-serine phosphorylation
positive regulation of translation in response to endoplasmic reticulum stress
positive regulation of T cell proliferation
T cell activation
positive regulation of GTPase activity
positive regulation of transcription from RNA polymerase II promoter
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
dendritic spine development
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of PERK-mediated unfolded protein response
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
