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Abnova
NCK2 Recombinant Rabbit Monoclonal Antibody
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Product Details
RAB02077
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to human NCK2.
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
50mM tris glycine, pH 7.4, with 40% glycerol, 150mM NaCl, 0.05% BSA
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The NCK family of SH2/SH3 adaptor proteins consists of two members, NCK1 and NCK2, which couple tyrosine kinase signaling, including the EGF and PDGF receptor-pathways, to downstream signaling proteins. The NCK2 protein binds human PDGFR-b (Tyr-1009); overexpression of NCK2 inhibits PDGF-induced membrane ruffling and lamellipod formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytoplasmic protein NCK2; Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; non-catalytic region of tyrosine kinase adaptor protein 2; noncatalytic region of tyrosine kinase, beta; SH2/SH3 adaptor protein NCK-beta
Gene Aliases: 4833426I10Rik; GRB4; Nck-2; NCK2; NCKbeta
UniProt ID: (Human) O43639, (Mouse) O55033
Entrez Gene ID: (Human) 8440, (Mouse) 17974, (Rat) 316369
immunological synapse formation
actin filament organization
signal transduction
signal complex assembly
epidermal growth factor receptor signaling pathway
regulation of epidermal growth factor-activated receptor activity
negative regulation of cell proliferation
vesicle-mediated transport
cell migration
lamellipodium assembly
positive regulation of actin filament polymerization
negative regulation of peptidyl-serine phosphorylation
positive regulation of translation in response to endoplasmic reticulum stress
positive regulation of T cell proliferation
T cell activation
positive regulation of GTPase activity
positive regulation of transcription from RNA polymerase II promoter
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
dendritic spine development
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of PERK-mediated unfolded protein response
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
regulation of translation
phosphorylation
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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