Search
Invitrogen
NCoR1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
产品信息
PA5150726
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.2 mg/mL
规格
20 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Highest antigen sequence identity to the following orthologs: Mouse- 85%, Rat- 84%.
Sequence of this protein is as follows: PPTSTFQNSP SALVSTPVRT KTSNRYSPES QAQSVHHQRP GSRVSPENLV DKSRGSRPGK SPERSHVSSE PYEPISPPQV PVVHEKQDSL LLLSQ
靶标信息
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: h KIAA1047; hCIT529I10; MGC104216; N-CoR; nrcr; nuclear receptor corepressor; Nuclear receptor corepressor 1; protein phosphatase 1, regulatory subunit 109; thyroid hormone- and retinoic acid receptor-associated corepressor 1; unnamed protein product
基因别名: hN-CoR; KIAA1047; N-CoR; N-CoR1; NCOR1; PPP1R109; TRAC1
UniProt ID: (Human) O75376
Entrez Gene ID: (Human) 9611
transcription regulatory region sequence-specific DNA binding
DNA binding
transcription corepressor activity
protein binding
ligand-dependent nuclear receptor binding
histone deacetylase binding
thyroid hormone receptor binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
regulation of cellular ketone metabolic process
locomotor rhythm
negative regulation of glycolytic process
negative regulation of transcription, DNA-templated
negative regulation of fatty acid metabolic process
negative regulation of JNK cascade
rhythmic process
spindle assembly
negative regulation of androgen receptor signaling pathway
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
