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Invitrogen
NCoR1 Monoclonal Antibody (7A7A9)
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产品信息
MA5-15447
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
7A7A9
抗原
Purified recombinant fragment of NCOR1 (aa1-192) expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-15447 targets NCOR1 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.
The MA5-15447 immunogen is purified recombinant fragment of NCOR1 (aa1-192) expressed in E. Coli.
靶标信息
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: h KIAA1047; hCIT529I10; MGC104216; N-CoR; nuclear receptor corepressor; Nuclear receptor corepressor 1; protein phosphatase 1, regulatory subunit 109; thyroid hormone- and retinoic acid receptor-associated corepressor 1
基因别名: hN-CoR; KIAA1047; N-CoR; N-CoR1; NCOR1; PPP1R109; TRAC1
UniProt ID: (Human) O75376
Entrez Gene ID: (Human) 9611
RNA polymerase II regulatory region DNA binding
RNA polymerase II activating transcription factor binding
chromatin binding
transcription corepressor activity
protein binding
ligand-dependent nuclear receptor binding
protein domain specific binding
estrogen receptor binding
nuclear hormone receptor binding
histone deacetylase binding
peroxisome proliferator activated receptor binding
transcription regulatory region DNA binding
retinoid X receptor binding
thyroid hormone receptor binding
chromatin/chromatin-binding, or -regulatory protein
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
skeletal muscle tissue development
lactation
circadian rhythm
positive regulation of cell proliferation
covalent chromatin modification
cerebellum development
cellular lipid metabolic process
negative regulation of JNK cascade
spindle assembly
regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
negative regulation of production of miRNAs involved in gene silencing by miRNA
regulation of fatty acid transport
