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Invitrogen
NDFIP1 Polyclonal Antibody
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产品信息
PA5-50172
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from C-terminal of human NDFIP1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody detects endogenous levels of total NDFIP1 protein.
靶标信息
The NEDD4 family-interacting protein 1 (NDFIP1) belongs to a small group of evolutionarily conserved proteins with three transmembrane domains and is an integral Golgi membrane protein. It is a potential target for ubiquitination by the Nedd4 family of proteins. NDFIP1 is strongly expressed in surviving neurons following acute cortical brain injury, and overexpression in cultured cortical neurons increased survival following growth factor starvation, suggesting that NDFIP1 may play a role in neuronal survival. NDFIP1 and the related protein NDFIP2 are thought to interact with and regulate multiple components of the EGF and PTEN/Akt signaling pathways. Recent studies suggest that NDFIP1 may also play a role in Th17 differentiation by limiting the production of proinflammatory cytokines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Breast cancer-associated protein SGA-1M; NEDD4 family-interacting protein 1; Nedd4 WW binding protein 5; NEDD4 WW domain-binding protein 5; Nedd4 WW-binding protein 5; Putative MAPK-activating protein PM13; Putative NF-kappa-B-activating protein 164; Putative NFKB and MAPK-activating protein
基因别名: 0610010M22Rik; N4WBP5; NDFIP1; PSEC0192; PSEC0223
UniProt ID: (Human) Q9BT67, (Rat) Q5U2S1, (Mouse) Q8R0W6
Entrez Gene ID: (Human) 80762, (Rat) 291609, (Mouse) 65113
regulation of myeloid leukocyte differentiation
negative regulation of type 2 immune response
cellular iron ion homeostasis
vacuolar transport
signal transduction
negative regulation of gene expression
metal ion transport
positive regulation of protein ubiquitination
negative regulation of transporter activity
negative regulation of interleukin-4 production
negative regulation of T cell proliferation
positive regulation of I-kappaB kinase/NF-kappaB signaling
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
regulation of lymphocyte differentiation
positive regulation of protein catabolic process
negative regulation of isotype switching to IgE isotypes
regulation of isotype switching to IgG isotypes
negative regulation of inflammatory response
negative regulation of protein transport
