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Invitrogen
NDP Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-44481
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the middle region of human NDP
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Peptide sequence: DPRRCMRHHY VDSISHPLYK CSSKMVLLAR CEGHCSQASR SEPLVSFSTV
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
靶标信息
NDP (Norrie disease protein), also known as norrin, is a secreted signaling protein encoded by the NDP gene that activates the canonical Wnt/β-catenin pathway by binding the Frizzled-4 (FZD4)/LRP5 receptor complex. It plays an essential role in retinal vascular development, maintenance of the blood-retina barrier, and inner ear vascularization. Loss-of-function variants in NDP cause Norrie disease and can also contribute to familial exudative vitreoretinopathy (FEVR).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: NDP; NDP, norrin cystine knot growth factor; Norrie disease (pseudoglioma); norrie disease protein; unnamed protein product; X-linked exudative vitreoretinopathy 2 protein
基因别名: EVR2; FEVR; ND
UniProt ID: (Human) Q00604
Entrez Gene ID: (Human) 4693
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