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Invitrogen
NDP Polyclonal Antibody
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Product Details
PA5-82059
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NDP. Recombinant protein control fragment (Product #RP-92199).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TDSSFIMDSD PRRCMRHHYV DSISHPLYKC SSKMVLLARC EGHCSQASRS EPLVSFSTVL KQPFRSSCHC CRPQTSKLKA LRLRCSGGMR LTATYRYILS CHCEECNS
Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 95%.
Target Information
ALDH4A1 belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NDP; NDP, norrin cystine knot growth factor; Norrie disease (pseudoglioma); Norrie disease protein; Norrin; unnamed protein product; X-linked exudative vitreoretinopathy 2 protein
Gene Aliases: EVR2; FEVR; ND; NDP
UniProt ID: (Human) Q00604
Entrez Gene ID: (Human) 4693
mitotic cell cycle
re-entry into mitotic cell cycle
action potential
angiogenesis
response to hypoxia
placenta development
blood vessel remodeling
lens development in camera-type eye
retinal pigment epithelium development
neural retina development
tricarboxylic acid cycle
transcription from RNA polymerase II promoter
glycine metabolic process
L-serine metabolic process
protein targeting to lysosome
glutathione metabolic process
inflammatory response
vacuole organization
transforming growth factor beta receptor signaling pathway
smoothened signaling pathway
nervous system development
visual perception
protein localization
cell proliferation
gene expression
retina layer formation
microglia differentiation
Wnt signaling pathway
dendrite development
protein ubiquitination
optic nerve development
neuron differentiation
retinal ganglion cell axon guidance
extracellular matrix-cell signaling
exploration behavior
endothelial cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
decidualization
response to axon injury
neuron apoptotic process
positive regulation of protein kinase B signaling
retina development in camera-type eye
retina morphogenesis in camera-type eye
canonical Wnt signaling pathway
retinal rod cell differentiation
establishment of blood-brain barrier
dendritic spine development
retina vasculature development in camera-type eye
retina vasculature morphogenesis in camera-type eye
retinal blood vessel morphogenesis
microglial cell proliferation
ubiquitin-dependent endocytosis
cellular response to hypoxia
retina blood vessel maintenance
Norrin signaling pathway
cone retinal bipolar cell differentiation
establishment of blood-retinal barrier
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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