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Invitrogen
NEFL Polyclonal Antibody
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NEFL Antibody (PA5-87394) in IHC (P)
Immunohistochemistry analysis of NEFL in paraffin-embedded human breast cancer using. Samples were incubated with NEFL Polyclonal antibody (Product # PA5-87394) using a dilution of 1:200 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-87394
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SSGSLMPSLE NLDLSQVAAI SNDLKSIRTQ EKAQLQDLND RFASFIERVH ELEQQNKVLE AELLVLRQKH SEPSRFRALY EQEIRDLRLA AEDATNEKQA LQGEREGLEE TLRNLQARYE EEVLSREDAE GRLMEARKGA DEAALARAEL EKRIDSLMDE ISFLKKVHEE EIAELQAQIQ YAQISVEMDV T
Positive Samples: MCF7
靶标信息
Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-L is the light or low molecular weight microfilament subunit and runs on SDS-PAGE gels at approximately 70 kDa. Neurofilament are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-H is the heavy or high molecular weight microfilament subunit and runs on SDS-PAGE gels in the range 180-220 kDa, with some variation in different species.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 68 kDa neurofilament protein; 68kDa neurofilament; FLJ53642; intermediate filament; light molecular weight neurofilament protein; N-FL; NEF3; NEFL; neurofilament; neurofilament 3; neurofilament protein; neurofilament protein, light chain; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament-l; neurofilament-light; NF-M; NFM; NLC; OTTHUMP00000196614; protein phosphatase 1, regulatory subunit 110; unnamed protein product
基因别名: CMT1F; CMT2E; CMTDIG; NF-L; NF68; NFL; PPP1R110
UniProt ID: (Human) P07196, (Rat) P19527, (Mouse) P08551
Entrez Gene ID: (Human) 4747, (Rat) 83613, (Mouse) 18039
structural constituent of cytoskeleton
protein binding
tubulin binding
protein domain specific binding
protein binding, bridging
identical protein binding
phospholipase binding
macromolecular complex binding
structural constituent of postsynaptic intermediate filament cytoskeleton
molecular condensate scaffold activity
anterograde axonal transport
retrograde axonal transport
response to toxic substance
axonal transport of mitochondrion
spinal cord development
hippocampus development
cerebral cortex development
neurofilament bundle assembly
response to peptide hormone
intermediate filament polymerization or depolymerization
intermediate filament organization
protein polymerization
response to corticosterone
regulation of synapse maturation
postsynaptic modulation of chemical synaptic transmission
postsynaptic intermediate filament cytoskeleton organization
response to sodium arsenite
response to acrylamide
microtubule cytoskeleton organization
peripheral nervous system axon regeneration
regulation of axon diameter
locomotion
negative regulation of neuron apoptotic process
intermediate filament polymerization
intermediate filament bundle assembly
neuron projection morphogenesis
positive regulation of axonogenesis
neuromuscular process controlling balance
neurofilament cytoskeleton organization
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