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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Reconstitute at 0.2 mg/mL in sterile PBS.
NENF is a secreted protein that is expressed in neurons but not glial cells of the brain. This protein has neurotrophic activity in primary cultured mouse neurons but not mitogenic activity in primary cultured mouse astrocytes. NENF activated mitogen-activated protein (MAP) and phosphotidylinositol-3 kinase pathways and could be inhibited by pertussis toxin but not receptor tyrosine kinases, suggesting that NENF acts through a Gi/Go-protein-coupled receptor.
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Protein Aliases: Cell immortalization-related protein 2; Neudesin; Neuron-derived neurotrophic factor; Protein GIG47; Secreted protein of unknown function; SPUF protein
Gene Aliases: CIR2; NENF; SPUF
Entrez Gene ID: (Human) 29937
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