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Immunogen sequence: PRKGRLIVCG HGTLERDGVF CLLSDDHGAS WRYGSGVSGI PYGQPKQEND FNPDECQPYE LPDGSVVINA RNQNNYHCHC RIVLRSYDAC DTLRPRDVTF DPELVDPVVA AGAVVTSSGI VFFSNPAHPE FRVNLTLRWS FSNGTSWRKE TVQLWPGPSG YSSLATLEGS MDGEEQAPQL YVLYEKGRNH YTESISVAKI SVYGTL
Positive Samples: Mouse liver, Rat liver; Cellular Location: Cell membrane, Cytoplasmic vesicle, Lumenal side, Lysosome lumen, Lysosome membrane, Peripheral membrane protein
NEU1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A. Mutations in NEU1 gene can lead to sialidosis.The protein encoded by this gene encodes the lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Acetylneuraminyl hydrolase; EC 3.2.1.18; exo-alpha-sialidase; FLJ93471; G9 sialidase; HLA-B-associated transcript 7; Lysosomal sialidase; N-acetyl-alpha-neuraminidase 1; sialidase 1; sialidase 1 (lysosomal sialidase); Sialidase-1
基因别名: AA407268; AA407316; Aglp; Apl; Bat-7; Bat7; G9; Map-2; NANH; NEU; Neu-1; NEU1; SIAL1
UniProt ID: (Human) Q99519, (Mouse) O35657
Entrez Gene ID: (Human) 4758, (Mouse) 18010, (Rat) 24591
分子生物学功能: hydrolase