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Invitrogen
NEURL1 Polyclonal Antibody
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FIGURE: 1 / 2
NEURL1 Antibody (PA5-99662) in ICC/IF
Immunocytochemistry analysis of NEURL1 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with NEURL1 polyclonal antibody (Product # PA5-99662) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-99662
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NEURL1(Accession O76050), corresponding to amino acid residues S218-A268.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Neuralized-1.
Target Information
NEURL is involved in the determination of cell fate in the neurogenic region of the embryo and plays a role in the determination of cell fate in the central nervous system. NEURL may act as a tumor suppressor whose inactivation could be associated with malignant progression of astrocytic tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase NEURL1; h neu; h neuralized 1; h-neu; h-neuralized 1; neuralized homolog; Neuralized-like protein 1A; RING finger protein 67; RING-type E3 ubiquitin transferase NEURL1
Gene Aliases: bA416N2.1; neu; neu-1; NEUR1; NEURL; NEURL1; NEURL1A; RNF67
UniProt ID: (Human) O76050
Entrez Gene ID: (Human) 9148
regulation of translation
protein monoubiquitination
Notch signaling pathway
sperm axoneme assembly
nervous system development
brain development
skeletal muscle tissue development
lactation
negative regulation of cell proliferation
sperm motility
positive regulation of apoptotic process
positive regulation of epidermal growth factor-activated receptor activity
negative regulation of Notch signaling pathway
positive regulation of long-term neuronal synaptic plasticity
positive regulation of filopodium assembly
positive regulation of dendritic spine development
cellular response to amino acid stimulus
positive regulation of synapse maturation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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