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Bethyl Laboratories
NF2 Polyclonal Antibody
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NF2 Antibody (A300-579A) in WB
Detection of Isoform 2 of human NF2 by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15, and 15 µg for WB; 1 mg for IP, 1/4 of IP reaction loaded) and NIH293 (50 µg for WB) cells. Antibody: Affinity purified rabbit anti-NF2 antibody BL2777 (Product # A300-579A) used for western blot at 0.1 µg/mL (A) and 1 µg/mL (B) for IP at 3 µg/mg lysate for IP (B). Isoform 2 of NF2 was also immunoprecipitated using rabbit ant-NF2 antibody BL2775, which is to an upstream epitope also found in isoform 1. Isoform 2 was not ... View More
产品信息
A300-579A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 550 and the C-terminus (residue 590) of human Neurofibromin 2.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Rat
靶标信息
NF2 encodes a protein, Merlin, that is similar to some members of the ERM family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. Merlin has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bilateral acoustic neurofibromatosis; Merlin; MGC123124; moesin-ezrin-radixin like; Moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromatosis type 2; neurofibromin 2 (bilateral acoustic neuroma); Neurofibromin-2; NF2; OTTHUMP00000199607; Schwannomerlin; Schwannomin; tumor suppressor; tumor suppressor; bilateral acoustic neuroma; Schwannomin/Merlin/Schwannomerlin; unnamed protein product
基因别名: ACN; BANF; merlin-1; NF2; SCH; SWNV
UniProt ID: (Human) P35240
Entrez Gene ID: (Human) 4771
MAPK cascade
mesoderm formation
negative regulation of cell-matrix adhesion
ectoderm development
brain development
negative regulation of cell proliferation
regulation of cell shape
negative regulation of Schwann cell proliferation
Schwann cell proliferation
regulation of gliogenesis
hippocampus development
negative regulation of cell-cell adhesion
actin cytoskeleton organization
cell differentiation
negative regulation of cell migration
regulation of protein stability
osteoblast proliferation
negative regulation of osteoblast proliferation
regulation of hippo signaling
regulation of cell proliferation
odontogenesis of dentin-containing tooth
regulation of apoptotic process
negative regulation of MAPK cascade
cell-cell junction organization
positive regulation of cell differentiation
negative regulation of JAK-STAT cascade
regulation of neurogenesis
positive regulation of stress fiber assembly
regulation of cell cycle
lens fiber cell differentiation
regulation of stem cell proliferation
regulation of protein localization to nucleus
regulation of organelle assembly
positive regulation of protein localization to early endosome
regulation of neural precursor cell proliferation
positive regulation of early endosome to late endosome transport
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