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Abnova
NF2 Polyclonal Antibody, MaxPab™
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产品信息
H00004771-B02P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NF2 (NP_861968.1, 1 a.a. approximately 507 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
规格
50 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEVK KQILDEKIYC PPEASVLLAS YAVQAKYGDY DPSVHKRGFL AQEELLPKRV INLYQMTPEM WEERITAWYA EHRGRARDEA EMEYLKIAQD LEMYGVNYFA IRNKKGTELL LGVDALGLHI YDPENRLTPK ISFPWNEIRN ISYSDKEFTI KPLDKKIDVF KFNSSKLRVN KLILQLCIGN HDLFMRRRKA DSLEVQQMKA QAREEKARKQ MERQRLAREK QMREEAERTR DELERRLLQM KEEATMANEA LMRSEETADL LAEKAQITEE EAKLLAQKAA EAEQEMQRIK ATAIRTEEEK RLMEQKVLEA EVLALKMAEE SERRAKEADQ LKQDLQEARE AERRAKQKLL EIATKPTYPP MNPIPAPLPP DIPSFNLIGD SLSFDFKDTD MKRLSMEIEK EKVEYMEKSK HLQEQLNELK TEIEALKLKE RETALDILHN ENSDRGGSSK HNTIKKPQAQ GRRPICI
靶标信息
NF2 encodes a protein, Merlin, that is similar to some members of the ERM family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. Merlin has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bilateral acoustic neurofibromatosis; Merlin; MGC123124; moesin-ezrin-radixin like; Moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromatosis type 2; neurofibromin 2 (bilateral acoustic neuroma); Neurofibromin-2; NF2; OTTHUMP00000199607; Schwannomerlin; Schwannomin; tumor suppressor; tumor suppressor; bilateral acoustic neuroma; Schwannomin/Merlin/Schwannomerlin; unnamed protein product
基因别名: ACN; BANF; merlin-1; NF2; SCH; SWNV
UniProt ID: (Human) P35240
Entrez Gene ID: (Human) 4771
MAPK cascade
mesoderm formation
negative regulation of cell-matrix adhesion
ectoderm development
brain development
negative regulation of cell proliferation
regulation of cell shape
negative regulation of Schwann cell proliferation
Schwann cell proliferation
regulation of gliogenesis
hippocampus development
negative regulation of cell-cell adhesion
actin cytoskeleton organization
cell differentiation
negative regulation of cell migration
regulation of protein stability
osteoblast proliferation
negative regulation of osteoblast proliferation
regulation of hippo signaling
regulation of cell proliferation
odontogenesis of dentin-containing tooth
regulation of apoptotic process
negative regulation of MAPK cascade
cell-cell junction organization
positive regulation of cell differentiation
negative regulation of JAK-STAT cascade
regulation of neurogenesis
positive regulation of stress fiber assembly
regulation of cell cycle
lens fiber cell differentiation
regulation of stem cell proliferation
regulation of protein localization to nucleus
regulation of organelle assembly
positive regulation of protein localization to early endosome
regulation of neural precursor cell proliferation
positive regulation of early endosome to late endosome transport
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