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Invitrogen
NFKBIL1 Polyclonal Antibody
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NFKBIL1 Antibody (PA5-23499) in WB
Western blot analysis of NFKBIL1 in HeLa cell lysate. Samples were incubated in NFKBIL1 polyclonal antibody (Product # PA5-23499 using a dilution of 3 µg/mL. Lanes 1 and 2 show HeLa cell lysate probed with pre-immune sera (1:5000) and NFKBIL1 polyclonal antibody, respectively.
产品信息
PA5-23499
产品规格
种属反应
Amphibian,
Bovine,
Dog,
Chimpanzee,
Horse,
Human,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Human NFKBIL1 (aa 331-349).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Suggested positive control: HeLa.
The amino acid sequence used as immunogen is 100% homologous in new world monkey, panda, mouse lemur, chimpanzee, orangutan, rhesus monkey, wild pig, 95% homologous in horse, rat, mouse, 89% homologous in frog, opossum, sea anemone and 74% homologous in platypus and carolina anole. Reacts with Frog.
Immunogen sequence: RRYLRVQQVR WHPDRFLQR
靶标信息
NF-kappa-B inhibitor-like protein 1 (NFKBIL1), also named Ikb like and IkbL1, is a 381 amino acid member of the inhibitor of NF-kappaB (IkappaB) family of proteins. NFKBIL1 contains two ANK repeats and is expressed in the rheumatoid synovial lining and sub-lining layers and co-localized in CD68+ and CD3+, but not Factor VIII+ cells. It is reported that defects in NFKBIL1 expression causes of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune features and affects the joints. Rheumatoid arthritis (RA) is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DADB-70P7.2; I-kappa-B-like protein; ikappaBL; Inhibitor of kappa B-like protein; inhibitor of Rel family transcription factors; NF-kappa-B inhibitor-like protein 1; NF-kappaB inhibitor-like protein 1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
基因别名: IkappaBL; IKBL; LST1; NFKBIL; NFKBIL1
UniProt ID: (Human) Q9UBC1, (Chimpanzee) Q861W0
Entrez Gene ID: (Bovine) 514369, (Human) 4795, (Horse) 100050027, (Dog) 481711, (Chimpanzee) 462558
I-kappaB kinase/NF-kappaB signaling
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
negative regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
cytoplasmic sequestering of transcription factor
cellular response to lipopolysaccharide
