Invitrogen

NGF Polyclonal Antibody

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NGF Polyclonal Antibody

Product Details

PA1-18381

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
-

ELISA (ELISA)

1-3 µg/mL
-
Product Specifications

Species Reactivity

Avian, Chicken, Human, Mouse, Rat

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Native mouse beta NGF purified from submaxillary salivary gland.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1077263

Product Specific Information

Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Glycerol (1:1) may be added for an additional stability.

Target Information

Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B nerve growth factor; b-NGF; beta ngf; Beta-nerve growth factor; Beta-NGF; BetaNGF; bNGF; MGC161426; MGC161428; Nerve growth factor; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta subunit; NGF b; NGF β; NGFbeta; NGFβ; β nerve growth factor; β NGF; βNGF

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Gene Aliases: Beta-NGF; HSAN5; NGF; NGFB

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UniProt ID: (Human) P01138, (Mouse) P01139, (Rat) P25427

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Entrez Gene ID: (Chicken) 396466, (Human) 4803, (Mouse) 18049, (Rat) 310738

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Function(s)
nerve growth factor receptor binding growth factor activity protein binding metalloendopeptidase inhibitor activity enzyme inhibitor activity receptor signaling protein activity receptor binding peptidase inhibitor activity molecular_function neurotrophic factor
Process(es)
transmembrane receptor protein tyrosine kinase signaling pathway peripheral nervous system development memory nerve development positive regulation of peptidyl-serine phosphorylation nerve growth factor signaling pathway negative regulation of neuron apoptotic process regulation of neuron differentiation positive regulation of collateral sprouting neuron projection morphogenesis modulation of synaptic transmission activation of MAPKK activity activation of cysteine-type endopeptidase activity involved in apoptotic process microtubule-based movement cell-cell signaling extrinsic apoptotic signaling pathway via death domain receptors positive regulation of gene expression nerve growth factor processing positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of Ras protein signal transduction neurotrophin TRK receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of axonogenesis positive regulation of cell proliferation adult locomotory behavior negative regulation of peptidase activity negative regulation of endopeptidase activity positive regulation of neuron projection development positive regulation of neuron maturation sensory perception of pain positive regulation of cell growth neuron projection development positive regulation of protein ubiquitination positive regulation of protein autophosphorylation intracellular signal transduction positive regulation of neuron differentiation positive regulation of axon extension regulation of neurotransmitter secretion positive regulation of sequence-specific DNA binding transcription factor activity regulation of release of sequestered calcium ion into cytosol positive regulation of neurotrophin TRK receptor signaling pathway neuron apoptotic process cellular response to acid chemical extrinsic apoptotic signaling pathway in absence of ligand positive regulation of stem cell proliferation negative regulation of type B pancreatic cell apoptotic process inflammatory response aging circadian rhythm response to radiation response to mechanical stimulus response to organic substance response to ozone response to organic cyclic compound response to lipopolysaccharide response to nicotine response to drug response to peptide hormone response to glucocorticoid response to electrical stimulus
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