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Antibodies Inc
NGL-2/LRRC4 Monoclonal Antibody (N50/36)
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产品信息
75-084
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N50/36
抗原
Fusion protein amino acids 550-652 of mouse NGL-2 (accession number AAG60620) produced recombinantly in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4
内含物
0.065% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
The LRRC4 gene, also known as netrin-G ligand 2 (NGL-2), is a brain-specific member of the leucine-rich repeat superfamily, playing a critical role in the central nervous system. Its expression is particularly high in areas such as the hippocampal CA1 and CA2 regions, as well as in granule cells of the dentate gyrus. LRRC4 is a known tumor suppressor gene associated with glioma suppression, as it regulates glioma cell growth, angiogenesis, and invasion through extensive signaling networks. It can participate in multiphase loops involving miRNA, transcription factors, and gene methylation modifications. This gene targets various genes involved in cell motility, impacting glioblastoma cell movement and polarization by binding to enhancer elements and activating transcription, notably the RAP1GAP gene. Its function and expression are crucial in maintaining normal brain function and hold potential implications in the management of gliomagenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Brain tumor-associated protein MBAG1; leucine rich repeat containing 4 protein; Leucine-rich repeat-containing protein 4; LIBG-like protein; LRRC4-like protein; Netrin-G2 ligand; NGL-2; NLG2; protein NGL-2
基因别名: Lrrc4; MBAG1; Nag14; NGL-2; NLG-2
UniProt ID: (Mouse) Q99PH1, (Rat) Q45R42
Entrez Gene ID: (Mouse) 192198, (Rat) 641521
