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Invitrogen
NKG2A (Monalizumab Biosimilar) Recombinant Humanized mouse Monoclonal Antibody
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NKG2A (Monalizumab Biosimilar) Antibody (MA5-42072) in SDS-PAGE
SDS-PAGE analysis of NKG2A (Monalizumab Biosimilar). Samples were run under reducing (R) and non-reducing (NR) conditions using NKG2A (Monalizumab Biosimilar) monoclonal antibody (Product # MA5-42072). The purity of the protein is greater than 95%.
产品信息
MA5-42072
产品规格
种属反应
Human
宿主/亚型
Artificial Control
/ IgG4, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human KLRC1/NKG2A/CD159a/CD94
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-lectin type II protein; CD159 antigen-like family member A; CD159a; killer cell lectin-like receptor subfamily C, member 1; natural killer cell lectin; natural killer group protein 2; NK cell receptor A; NKG2-1/B activating NK receptor; NKG2-A gene; NKG2-A/B type II integral membrane protein; NKG2-A/B-activating NK receptor; NKG2-A/NKG2-B type II integral membrane protein; NKG2-B gene
基因别名: CD159A; KLRC1; NKG2; NKG2A
UniProt ID: (Human) P26715
Entrez Gene ID: (Human) 3821
negative regulation of T cell mediated cytotoxicity
stimulatory C-type lectin receptor signaling pathway
adaptive immune response
CD8-positive, gamma-delta intraepithelial T cell differentiation
immune system process
immune response-regulating cell surface receptor signaling pathway
natural killer cell inhibitory signaling pathway
cell surface receptor signaling pathway
regulation of natural killer cell activation
regulation of natural killer cell mediated cytotoxicity
innate immune response
negative regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity
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