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Invitrogen
NKp46 Polyclonal Antibody
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NKp46 Antibody (PA5-102860) in WB
Western blot was performed using Anti-NKp46 Polyclonal Antibody (Product # PA5-102860) and a 46 kDa band corresponding to Natural cytotoxicity triggering receptor 1 was observed in NK-92 cells which was upregulated upon serum starvation followed by Human IL-2 treatment. Membrane enriched extracts (30 µg lysate) of NK-92 (Lane 1), NK-92 treated with Human IL-2 (20 ng/mL for 24h) (Lane 2) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane... View More
产品信息
PA5-102860
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
C. elegans,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NCR1(Accession O76036), corresponding to amino acid residues C144-Y194.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total NCR1.
靶标信息
CD335, also known as NKp46 or NCR1, is a member of the natural cytotoxicity receptor family, which includes NKp30 and NKp44. This type I transmembrane glycoprotein is expressed on NK cells and plays a crucial role in activating and expanding resting NK cells through interactions with dendritic cells. CD335 enhances the ability of NK cells to eliminate tumor and virus-infected cells, such as those infected by influenza. CD335 consists of two Ig-like domains and is related to leukocyte immunoglobulin-like receptors (LIR) and killer inhibitory receptors (KIR). It contributes to the increased efficiency of activated NK cells in mediating tumor cell lysis. Additionally, CD335 interacts with pancreatic beta cells during the development of type 1 diabetes, highlighting its involvement in both immune defense and autoimmune processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 1-Mar; Activating receptor 1; CD335; hNKp46; Ly-94; Lymphocyte antigen 94; Lymphocyte antigen 94 homolog; lymphocyte antigen 94 homolog (activating NK-receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); mAR-1; MAR1 (mouse activating receptor 1); mNKp46; Natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; natural killer cell receptor; NK cell-activating receptor; NK receptor KILR-1; NK-p46; NK-p46); NKACTR; rAR-1; rat-activating receptor 1
基因别名: Ar1; CD335; KILR-1; Kilr1; LY94; NCR1; NK-p46; NKP46
UniProt ID: (Human) O76036, (Rat) Q9Z0H5, (Mouse) Q8C567
Entrez Gene ID: (Human) 9437, (Rat) 117547, (Mouse) 17086
